Ho Yee Joyce Fung, Ph.D.

Ho Yee Joyce Fung, Ph.D.

Education

Positions

Honors and Awards

Publications

  1. Fung, H.Y.J., McKibben, K. M., Ramirez, J., Gupta, K., & Rhoades, E. (2020). Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes. Structure (London, England : 1993), 28(3), 378–384.e4.
  2. Fu, S. C., Fung, H.Y.J., Çağatay, T., Baumhardt, J., & Chook, Y. M. (2018). Correlation of CRM1-NES affinity with nuclear export activity. Molecular biology of the cell, 29(17), 2037–2044.
  3. Pinarbasi, E. S., Çağatay, T., Fung, H.Y.J., Li, Y. C., Chook, Y. M., & Thomas, P. J. (2018). Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Scientific reports, 8(1), 7083.
  4. Yoshizawa, T.*, Ali, R.*, Jiou, J., Fung, H.Y.J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K., & Chook, Y. M. (2018). Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173(3), 693–705.e22. *These authors contributed equally
  5. Fung, H.Y.J.*, Birol, M.*, & Rhoades, E.* (2018). IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies. Current opinion in structural biology, 49, 36–43. *These authors contributed equally
  6. Fung, H.Y.J., Fu, S. C., & Chook, Y. M. (2017). Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. eLife, 6, e23961.
  7. Hing, Z. A.*, Fung, H.Y.J.*, Ranganathan, P.*, Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M., … Lapalombella, R. (2016). Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30(12), 2364–2372. *These authors contributed equally
  8. Fung, H.Y.J., Fu, S.C., Brautigam, C.A. and Chook, Y.M. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. (2015) eLife;4:e10034.
  9. Pope, W. H., Bowman, C. A., Russell, D. A., Jacobs-Sera, D., Asai, D. J., Cresawn, S. G., Jacobs, W. R., Hendrix, R. W., Lawrence, J. G., Hatfull, G. F., Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science, Phage Hunters Integrating Research and Education, & Mycobacterial Genetics Course (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife, 4, e06416.
  10. Haines, J.D., Herbin, O., de la Hera, B., Vidaurre, O.G., Moy, G.A., Sun, Q., Fung, H.Y.J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y.M., Kuhlmann, T., Kidd, G.J., Shacham, S. and Casaccia, P. "Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination", Nat Neurosci. 2015 Apr;18(4):511-20.
  11. Fung, H.Y.J. and Chook Y.M. "Atomic basis of CRM1-cargo recognition, release and inhibition", Semin. Cancer Biol. 2014: 52-61
  12. Xie, Y., Fung, H.Y.J., Newberry, E.P., Kennedy, S., Luo, J., Crooke, R.M., Graham, M.J., Davidson, N.O. "Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice", J. Lipid Res. 2014 Mar; 55(3): 540-8.

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