Ho Yee Joyce Fung, Ph.D.

Education

• Washington University in St. Louis, A.B., Biology-Biochemistry, 2012
• UT Southwestern Medical Center, Ph.D., Molecular Biophysics, 2017

Positions

• 2023-Present — Assistant Professor, Structural Biology Lab, Department of Biophysics, UT Southwestern Medical Center
• 2022-Present — Instructor, Yuh Min Chook Lab, UT Southwestern Medical Center
• 2019-2022 — Assistant Instructor, Yuh Min Chook Lab, UT Southwestern Medical Center
• 2017-2019 — Postdoctoral Researcher, Department of Chemistry, Elizabeth Rhoades Lab, University of Pennsylvania
• 2012-2017 — Graduate Student, Molecular Biophysics Graduate Program, UT Southwestern Medical Center

Honors and Awards

• 2021, Gilman Special Opportunities Awards
• 2017, Dean’s Discretionary Award, UTSW
• 2017, The Alfred Gilman Memorial Student Award for Excellence in Research, UTSW
• 2016, The Protein Society Hans Neurath Outstanding Promise Travel Award
• 2015, Best Talk, UTSW Molecular Biophysics Research Symposium
• 2015-2017, HHMI International Student Research Fellowship
• 2014-2015, The Croucher Foundation Scholarship

Publications

1. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. J Cell Biol. 2025 Jan 6;224(1):e202408193.
2. Hudman-Wing CE, Fung HYJ, Cagatay T, Kwanten B, Niesman AB, Gharghabi M, Permentier B, Shakya B, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM. Allosteric degraders induce CRL5 ASB8 mediated degradation of XPO1. bioRxiv [Preprint]. 2024 Oct 11:2024
3. Fung HYJ, Mittal SR, Niesman AB, Jiou J, Shakya B, Yoshizawa T, Cansizoglu AE, Rout MP, Chook YM. Phosphate-dependent nuclear export via a novel NES class recognized by exportin Msn5. bioRxiv [Preprint]. 2024 Aug 12:2024
4. Gonzalez A, Kim HJ, Freibaum BD, Fung HYJ, Brautigam CA, Taylor JP, Chook YM. A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 linked to neurodevelopmental disorders. Structure. 2023 Aug 3;31(8):924-934.e4.
5. Fung HYJ, Chook YM. Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1. Methods Mol Biol. 2022;2502:285-297.
6. Fung HYJ, Chook YM. Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1. Methods Mol Biol. 2022;2502:245-256.
7. Wing CE, Fung HYJ, Chook YM. Karyopherin-mediated nucleocytoplasmic transport. Nat Rev Mol Cell Biol. 2022 Jan 20.
8. Fung HYJ, Niesman A, Chook YM. An update to the CRM1 cargo/NES database NESdb. Mol Biol Cell. 2021 Mar 15;32(6):467-469
9. Fung, H.Y.J., McKibben, K. M., Ramirez, J., Gupta, K., & Rhoades, E. (2020). Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes. Structure (London, England : 1993), 28(3), 378–384.e4.
10. Fu, S. C., Fung, H.Y.J., Çağatay, T., Baumhardt, J., & Chook, Y. M. (2018). Correlation of CRM1-NES affinity with nuclear export activity. Molecular biology of the cell, 29(17), 2037–2044.
11. Pinarbasi, E. S., Çağatay, T., Fung, H.Y.J., Li, Y. C., Chook, Y. M., & Thomas, P. J. (2018). Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Scientific reports, 8(1), 7083.
12. Yoshizawa, T.*, Ali, R.*, Jiou, J., Fung, H.Y.J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K., & Chook, Y. M. (2018). Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173(3), 693–705.e22. *These authors contributed equally
13. Fung, H.Y.J.*, Birol, M.*, & Rhoades, E.* (2018). IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies. Current opinion in structural biology, 49, 36–43. *These authors contributed equally
14. Fung, H.Y.J., Fu, S. C., & Chook, Y. M. (2017). Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. eLife, 6, e23961.
15. Hing, Z. A.*, Fung, H.Y.J.*, Ranganathan, P.*, Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M., … Lapalombella, R. (2016). Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30(12), 2364–2372. *These authors contributed equally
16. Fung, H.Y.J., Fu, S.C., Brautigam, C.A. and Chook, Y.M. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. (2015) eLife;4:e10034.
17. Pope, W. H., Bowman, C. A., Russell, D. A., Jacobs-Sera, D., Asai, D. J., Cresawn, S. G., Jacobs, W. R., Hendrix, R. W., Lawrence, J. G., Hatfull, G. F., Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science, Phage Hunters Integrating Research and Education, & Mycobacterial Genetics Course (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife, 4, e06416.
18. Haines, J.D., Herbin, O., de la Hera, B., Vidaurre, O.G., Moy, G.A., Sun, Q., Fung, H.Y.J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y.M., Kuhlmann, T., Kidd, G.J., Shacham, S. and Casaccia, P. "Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination", Nat Neurosci. 2015 Apr;18(4):511-20.
19. Fung, H.Y.J. and Chook Y.M. "Atomic basis of CRM1-cargo recognition, release and inhibition", Semin. Cancer Biol. 2014: 52-61
20. Xie, Y., Fung, H.Y.J., Newberry, E.P., Kennedy, S., Luo, J., Crooke, R.M., Graham, M.J., Davidson, N.O. "Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice", J. Lipid Res. 2014 Mar; 55(3): 540-8.

Contact

• [email protected]
  214-645-6168