
Ho Yee Joyce Fung, Ph.D.
Education
- Washington University in St. Louis, A.B., Biology-Biochemistry, 2012
- UT Southwestern Medical Center, Ph.D., Molecular Biophysics, 2017
Positions
- 2022-Present — Instructor, Yuh Min Chook Lab, UT Southwestern Medical Center
- 2019-2022 — Assistant Instructor, Yuh Min Chook Lab, UT Southwestern Medical Center
- 2017-2019 — Postdoctoral Researcher, Department of Chemistry, Elizabeth Rhoades Lab, University of Pennsylvania
- 2012-2017 — Graduate Student, Molecular Biophysics Graduate Program, UT Southwestern Medical Center
Honors and Awards
- 2021, Gilman Special Opportunities Awards
- 2017, Dean’s Discretionary Award, UTSW
- 2017, The Alfred Gilman Memorial Student Award for Excellence in Research, UTSW
- 2016, The Protein Society Hans Neurath Outstanding Promise Travel Award
- 2015, Best Talk, UTSW Molecular Biophysics Research Symposium
- 2015-2017, HHMI International Student Research Fellowship
- 2014-2015, The Croucher Foundation Scholarship
Publications
- Fung HYJ, Chook YM. Crystallization of Nuclear Export Signals or Small-Molecule Inhibitors Bound to Nuclear Exporter CRM1. Methods Mol Biol. 2022;2502:285-297.
- Fung HYJ, Chook YM. Binding Affinity Measurement of Nuclear Export Signal Peptides to Their Exporter CRM1. Methods Mol Biol. 2022;2502:245-256.
- Wing CE, Fung HYJ, Chook YM. Karyopherin-mediated nucleocytoplasmic transport. Nat Rev Mol Cell Biol. 2022 Jan 20.
- Fung HYJ, Niesman A, Chook YM. An update to the CRM1 cargo/NES database NESdb. Mol Biol Cell. 2021 Mar 15;32(6):467-469
- Fung, H.Y.J., McKibben, K. M., Ramirez, J., Gupta, K., & Rhoades, E. (2020). Structural Characterization of Tau in Fuzzy Tau:Tubulin Complexes. Structure (London, England : 1993), 28(3), 378–384.e4.
- Fu, S. C., Fung, H.Y.J., Çağatay, T., Baumhardt, J., & Chook, Y. M. (2018). Correlation of CRM1-NES affinity with nuclear export activity. Molecular biology of the cell, 29(17), 2037–2044.
- Pinarbasi, E. S., Çağatay, T., Fung, H.Y.J., Li, Y. C., Chook, Y. M., & Thomas, P. J. (2018). Active nuclear import and passive nuclear export are the primary determinants of TDP-43 localization. Scientific reports, 8(1), 7083.
- Yoshizawa, T.*, Ali, R.*, Jiou, J., Fung, H.Y.J., Burke, K. A., Kim, S. J., Lin, Y., Peeples, W. B., Saltzberg, D., Soniat, M., Baumhardt, J. M., Oldenbourg, R., Sali, A., Fawzi, N. L., Rosen, M. K., & Chook, Y. M. (2018). Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites. Cell, 173(3), 693–705.e22. *These authors contributed equally
- Fung, H.Y.J.*, Birol, M.*, & Rhoades, E.* (2018). IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies. Current opinion in structural biology, 49, 36–43. *These authors contributed equally
- Fung, H.Y.J., Fu, S. C., & Chook, Y. M. (2017). Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. eLife, 6, e23961.
- Hing, Z. A.*, Fung, H.Y.J.*, Ranganathan, P.*, Mitchell, S., El-Gamal, D., Woyach, J. A., Williams, K., Goettl, V. M., Smith, J., Yu, X., Meng, X., Sun, Q., Cagatay, T., Lehman, A. M., Lucas, D. M., Baloglu, E., Shacham, S., Kauffman, M. G., Byrd, J. C., Chook, Y. M., … Lapalombella, R. (2016). Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30(12), 2364–2372. *These authors contributed equally
- Fung, H.Y.J., Fu, S.C., Brautigam, C.A. and Chook, Y.M. Structural determinants of nuclear export signal orientation in binding to exportin CRM1. (2015) eLife;4:e10034.
- Pope, W. H., Bowman, C. A., Russell, D. A., Jacobs-Sera, D., Asai, D. J., Cresawn, S. G., Jacobs, W. R., Hendrix, R. W., Lawrence, J. G., Hatfull, G. F., Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science, Phage Hunters Integrating Research and Education, & Mycobacterial Genetics Course (2015). Whole genome comparison of a large collection of mycobacteriophages reveals a continuum of phage genetic diversity. eLife, 4, e06416.
- Haines, J.D., Herbin, O., de la Hera, B., Vidaurre, O.G., Moy, G.A., Sun, Q., Fung, H.Y.J., Albrecht, S., Alexandropoulos, K., McCauley, D., Chook, Y.M., Kuhlmann, T., Kidd, G.J., Shacham, S. and Casaccia, P. "Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination", Nat Neurosci. 2015 Apr;18(4):511-20.
- Fung, H.Y.J. and Chook Y.M. "Atomic basis of CRM1-cargo recognition, release and inhibition", Semin. Cancer Biol. 2014: 52-61
- Xie, Y., Fung, H.Y.J., Newberry, E.P., Kennedy, S., Luo, J., Crooke, R.M., Graham, M.J., Davidson, N.O. "Hepatic Mttp deletion reverses gallstone susceptibility in L-Fabp knockout mice", J. Lipid Res. 2014 Mar; 55(3): 540-8.
Contact
- [email protected]
214-645-6168