Ashley Brower Niesman

Education

• Marymount Manhattan College, B.S., Biology, 2007

Positions

• 2023-present — Senior Research Associate and Lab Manager, Department of Biophysics, UT Southwestern Medical Center
• 2013-present — Senior Research Associate and Lab Manager, Department of Pharmacology, UT Southwestern Medical Center
• 2012-2013 — Research Assistant II and Lab Manager, Department of Pharmacology, UT Southwestern Medical Center
• 2008-2012 — Laboratory Supervisor, Marymount Manhattan College
• 2006-2007 — Research Intern, Memorial Sloan Kettering Cancer Center

Publications

1. Fung HYJ, Mittal SR, Niesman AB, Jiou J, Shakya B, Yoshizawa T, Cansizoglu AE, Rout MP, Chook YM. Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5. Nat Commun. 2025 Mar 16;16(1):2580.
2. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. J Cell Biol. 2025 Jan 6;224(1):e202408193.
3. Hudman-Wing CE, Fung HYJ, Cagatay T, Kwanten B, Niesman AB, Gharghabi M, Permentier B, Shakya B, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM. Allosteric degraders induce CRL5 ASB8 mediated degradation of XPO1. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617049.
4. Fung HYJ, Mittal SR, Niesman AB, Jiou J, Shakya B, Yoshizawa T, Cansizoglu AE, Rout MP, Chook YM.< Phosphate-dependent nuclear export via a novel NES class recognized by exportin Msn5. bioRxiv [Preprint]. 2024 Aug 12:2024.08.12.607649.
5. Fung HYJ, Niesman A, Chook YM. An update to the CRM1 cargo/NES database NESdb. Mol Biol Cell. 2021 Mar 15;32(6):467-469.
6. Gonzalez A, Mannen T, Çağatay T, Fujiwara A, Matsumura H, Niesman AB, Brautigam CA, Chook YM, Yoshizawa T. Mechanism of karyopherin-β2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X). Sci Rep. 2021 Feb 12;11(1):3754.
7. Volpon, L., Culjkovic-Kraljacic, B., Osborne, M. J., Ramteke, A., Sun, Q., Niesman, A., Chook, Y. M., & Borden, K. L. (2016). Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E. Proceedings of the National Academy of Sciences of the United States of America, 113(19), 5263–5268.

Contact

• [email protected]
  214-645-6168