Natália Bernardes, Ph.D.

Education

• São Paulo State University , B.Sc., Biotechnology Engineering, 2012
• São Paulo State University , M.Sc., General and Applied Biology, 2014
• São Paulo State University , Ph.D., General and Applied Biology, 2018

Positions

• 2019-present — Postdoctoral Scholar, UT Southwestern Medical Center

Honors and Awards

• 2019-Present, Mary Kay Postdoctoral Scholar Award
• 2014-2018, Doctorate, São Paulo Research Foundation, FAPESP
• 2016, Research Internship Abroad, Doctorate, São Paulo Research Foundation, FAPESP
• 2014-2016, Masters, São Paulo Research Foundation, FAPESP

Publications

1. Fung HYJ, Jiou J, Niesman AB, Bernardes NE, Chook YM. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. J Cell Biol. 2025 Jan 6;224(1):e202408193.
2. Bernardes NE, Chook YM. WW domains: A globular NLS recognized by importin-α. J Cell Biol. 2024 Jun 3;223(6):e202405003. doi: 10.1083/jcb.202405003. Epub 2024 May 20.
3. Fung HYJ, Neisman AB, Bernardes NE, Jiou J, Chook YM. Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus. bioRxiv [Preprint]. 2024 Apr 23.
4. Jiou J, Shaffer JM, Bernades NE, Fung HYJ, Kikumoto Dias J, D'Arcy S, Chook YM. Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29)
5. Bernardes NE, Fung HYJ, Li Y, Chen Z, Chook YM. Structure of IMPORTIN-4 bound to the H3-H4-ASF1 histone-histone chaperone complex. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38).
6. Natalia Elisa Bernardes, Yuh Min Chook; Nuclear import of histones. Biochem Soc Trans 18 December 2020; 48 (6): 2753–2767.
7. Bernardes, N. E., Fukuda, C. A., da Silva, T. D., de Oliveira, H. C., de Barros, A. C., Dreyer, T. R., Bertolini, M. C., & Fontes, M. (2020). Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Scientific reports, 10(1), 1458.
8. Bernardes, N. E., Takeda, A., Dreyer, T. R., Cupertino, F. B., Virgilio, S., Pante, N., Bertolini, M. C., & Fontes, M. (2017). Nuclear transport of the Neurospora crassa NIT-2 transcription factor is mediated by importin-α. The Biochemical journal, 474(24), 4091–4104.
9. Virgilio, S., Cupertino, F. B., Bernardes, N. E., Freitas, F. Z., Takeda, A. A., Fontes, M. R., & Bertolini, M. C. (2016). Molecular Components of the Neurospora crassa pH Signaling Pathway and Their Regulation by pH and the PAC-3 Transcription Factor. PloS one, 11(8), e0161659.
10. Bernardes, N. E., Takeda, A. A., Dreyer, T. R., Freitas, F. Z., Bertolini, M. C., & Fontes, M. R. (2015). Structure of Importin-α from a Filamentous Fungus in Complex with a Classical Nuclear Localization Signal. PloS one, 10(6), e0128687.
11. Bernardes, N. E., Takeda, A. A., Freitas, F. Z., Bertolini, M. C., & Fontes, M. R. (2014). Crystallization and preliminary X-ray crystallographic analysis of importin-α from Neurospora crassa. Acta crystallographica. Section F, Structural biology communications, 70(Pt 4), 501–504.
12. Takeda, A. A., Freitas, F. Z., Magro, A. J., Bernardes, N. E., Fernandes, C. A., Gonçalves, R. D., Bertolini, M. C., & Fontes, M. R. (2013). Biophysical characterization of the recombinant importin-α from Neurospora crassa. Protein and peptide letters, 20(1), 8–16.

Contact

• [email protected]
  214-645-6168